The 26-year-old was seen to by Milan medical staff soon after and substituted. While he limped off the field on his own accord, Pulisic is now a doubt for the crucial game against Juventus on Saturday.
Pulisic missed most of December with a calf injury and returned to the team in style, scoring in both the semifinal and final of the Italian Super Cup.
He has five goals and four assists for MIlan in Serie A this season, tied for the team’s best in both categories.
Milan went on to beat Como 2-1, with defender Theo Hernández and forward Rafael Leão scoring in the second half.