Liverpool, Manchester City and Aston Villa will all hope to close the gap on Arsenal in a bumper morning of Premier League action.
The Gunners went five points clear at the top of the table after Declan Rice’s last-gasp winner against Luton Town.
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But that lead could be cut to two if Liverpool beat Sheffield United at Bramall Lane
The clash is Chris Wilder’s first game in charge back at the Blades after he replaced Paul Heckingbottom.
Manchester City travel to Villa but will be without talismanic midfielder Rodri and attacking duo Jeremy Doku and Jack Grealish.
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A win for Villa would also set a new club record of 14 consecutive home wins.
Manchester United also welcome Chelsea to Old Trafford as under-fire Red Devils boss Erik ten Hag looks to silence the critics.
FULL PREMIER LEAGUE RESULTS
Sheffield United v Liverpool
Fulham v Nottingham Forest
Crystal Palace v Bournemouth
Brighton v Brentford
Manchester United v Chelsea
Aston Villa v Manchester City
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