The two-time reigning premiers Penrith face the club that looks destined to become the two-time reigning wooden spooners – the Wests Tigers.
The Panthers are unbackable favourites against the Wests Tigers in Bathurst on Saturday night and Nathan Cleary will play despite chatter he may be rested.
MATCH CENTRE: Penrith Panthers v Wests Tigers, teams, stats, video
But they are set to be without bench star Spencer Leniu (calf) and 21-year-old Liam Henry will be called in for just his second NRL appearance.
Tigers speedster Charlie Staines has been sidelined indefinitely after suffering a stomach injury and David Nofoaluma has taken his place on the wing. Brent Naden returns from a collarbone blow and takes Asu Kepaoa’s spot.
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