The Broncos will be without skipper Adam Reynolds when the Cowboys host Brisbane in a blockbuster derby at Queensland Country Bank Stadium.
Jock Madden replaces Reynolds at halfback due to a groin injury for the Brisbane captain.
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Bench forward Kobe Hetherington (back cork) is also out and replaced by Xavier Willison on the pine.
Brendan Piakura (illness) and Jesse Arthars (suspension) are set to return, while Jordan Riki is bidding for a comeback from injury.
For the Cowboys Valentine Holmes is suspended for the rest of the regular season, with Kyle Feldt coming in to the centres.
Hooker Reece Robson is expected to play despite suffering a head knock in the closing stages of the Titans game.
The second placed Broncos need to win to keep the pressure on the Panthers for the minor premiership, while the eighth placed Cowboys need to win to stay in the top eight.
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